Children on dialysis as well as renal transplanted children report severely impaired health-related quality of life (2023)

Splinter, A., Tjaden, L. A., Haverman, L., Adams, B., Collard, L., Cransberg, K., van Dyck, M., Van Hoeck, K. J., Hoppe, B., Koster-Kamphuis, L., Lilien, M. R., Raes, A., Taylan, C., Grootenhuis, M. A., & Groothoff, J. W. (2018). Children on dialysis as well as renal transplanted children report severely impaired health-related quality of life. Quality of Life Research, 27(6), 1445-1454. https://doi.org/10.1007/s11136-018-1789-4

Splinter, Anouck ; Tjaden, Lidwien A. ; Haverman, Lotte et al. / Children on dialysis as well as renal transplanted children report severely impaired health-related quality of life. In: Quality of Life Research. 2018 ; Vol. 27, Nr. 6. blz. 1445-1454.

@article{64f81c2ab10d4bd48cdea34cb30cafc5,

title = "Children on dialysis as well as renal transplanted children report severely impaired health-related quality of life",

abstract = "Objectives: To assess health-related quality of life (HRQoL) across three renal replacement therapy modalities (preemptive transplant, non-preemptive transplant, and dialysis) in comparison with the healthy norm and other chronic health conditions, and to explore related patient factors. Study design: All prevalent end-stage renal disease (ESRD) patients aged 8–18years who spent at least 6months on their current treatment modality in the Netherlands, Belgium, and part of Germany were approached to complete the Pediatric Quality of Life Inventory 4.0 (PedsQL{\texttrademark}) questionnaire. We determined the differences between groups on PedsQL{\texttrademark} mean scores, the proportion of children with an impaired HRQoL (≥ 1 SD lower than the healthy norm), the proportion of problems on individual items of the PedsQL{\texttrademark}, and the effect of time on current treatment. Linear regression models were used to explore determinants of HRQoL. Results: 192 out of 278 patients (20% preemptive transplant, 58% non-preemptive transplant, 22% dialysis) filled in the PedsQL{\texttrademark} (response rate 69%). Independent of treatment modality, patients had significantly lower mean scores and consequently higher proportions of impaired HRQoL on almost all domains compared to the healthy norm and other chronic health conditions. Patients with a preemptive transplant only reported higher scores on physical health compared to the other treatment modalities. Having comorbidities was the most important determinant associated with lower HRQoL scores. Conclusion: Dialysis and renal transplantation both have a severe impact on the HRQoL of children with ESRD. Physicians should be aware of this continuous burden. Furthermore, to develop tailored interventions for children with ESRD, qualitative studies are needed to gain more insight in the determinants of HRQoL in the different treatment modalities.",

keywords = "Adolescents, End-stage renal disease, Health-related quality of life, Pediatrics, Renal replacement therapy",

author = "Anouck Splinter and Tjaden, {Lidwien A.} and Lotte Haverman and Brigitte Adams and Laure Collard and Karlien Cransberg and {van Dyck}, Maria and {Van Hoeck}, {Koen J.} and Bernd Hoppe and Linda Koster-Kamphuis and Lilien, {Marc R.} and Ann Raes and Christina Taylan and Grootenhuis, {Martha A.} and Groothoff, {Jaap W.}",

note = "Publisher Copyright: {\textcopyright} 2018, The Author(s).",

year = "2018",

month = jun,

day = "1",

doi = "10.1007/s11136-018-1789-4",

language = "English",

volume = "27",

pages = "1445--1454",

journal = "Quality of Life Research",

issn = "0962-9343",

publisher = "Springer Netherlands",

number = "6",

}

Splinter, A, Tjaden, LA, Haverman, L, Adams, B, Collard, L, Cransberg, K, van Dyck, M, Van Hoeck, KJ, Hoppe, B, Koster-Kamphuis, L, Lilien, MR, Raes, A, Taylan, C, Grootenhuis, MA & Groothoff, JW 2018, 'Children on dialysis as well as renal transplanted children report severely impaired health-related quality of life', Quality of Life Research, vol. 27, nr. 6, blz. 1445-1454. https://doi.org/10.1007/s11136-018-1789-4

Children on dialysis as well as renal transplanted children report severely impaired health-related quality of life. / Splinter, Anouck; Tjaden, Lidwien A.; Haverman, Lotte et al.
In: Quality of Life Research, Vol. 27, Nr. 6, 01.06.2018, blz. 1445-1454.

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

TY - JOUR

T1 - Children on dialysis as well as renal transplanted children report severely impaired health-related quality of life

AU - Splinter, Anouck

AU - Tjaden, Lidwien A.

AU - Haverman, Lotte

AU - Adams, Brigitte

AU - Collard, Laure

AU - Cransberg, Karlien

AU - van Dyck, Maria

AU - Van Hoeck, Koen J.

AU - Hoppe, Bernd

AU - Koster-Kamphuis, Linda

AU - Lilien, Marc R.

AU - Raes, Ann

AU - Taylan, Christina

AU - Grootenhuis, Martha A.

AU - Groothoff, Jaap W.

N1 - Publisher Copyright:© 2018, The Author(s).

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Objectives: To assess health-related quality of life (HRQoL) across three renal replacement therapy modalities (preemptive transplant, non-preemptive transplant, and dialysis) in comparison with the healthy norm and other chronic health conditions, and to explore related patient factors. Study design: All prevalent end-stage renal disease (ESRD) patients aged 8–18years who spent at least 6months on their current treatment modality in the Netherlands, Belgium, and part of Germany were approached to complete the Pediatric Quality of Life Inventory 4.0 (PedsQL™) questionnaire. We determined the differences between groups on PedsQL™ mean scores, the proportion of children with an impaired HRQoL (≥ 1 SD lower than the healthy norm), the proportion of problems on individual items of the PedsQL™, and the effect of time on current treatment. Linear regression models were used to explore determinants of HRQoL. Results: 192 out of 278 patients (20% preemptive transplant, 58% non-preemptive transplant, 22% dialysis) filled in the PedsQL™ (response rate 69%). Independent of treatment modality, patients had significantly lower mean scores and consequently higher proportions of impaired HRQoL on almost all domains compared to the healthy norm and other chronic health conditions. Patients with a preemptive transplant only reported higher scores on physical health compared to the other treatment modalities. Having comorbidities was the most important determinant associated with lower HRQoL scores. Conclusion: Dialysis and renal transplantation both have a severe impact on the HRQoL of children with ESRD. Physicians should be aware of this continuous burden. Furthermore, to develop tailored interventions for children with ESRD, qualitative studies are needed to gain more insight in the determinants of HRQoL in the different treatment modalities.

AB - Objectives: To assess health-related quality of life (HRQoL) across three renal replacement therapy modalities (preemptive transplant, non-preemptive transplant, and dialysis) in comparison with the healthy norm and other chronic health conditions, and to explore related patient factors. Study design: All prevalent end-stage renal disease (ESRD) patients aged 8–18years who spent at least 6months on their current treatment modality in the Netherlands, Belgium, and part of Germany were approached to complete the Pediatric Quality of Life Inventory 4.0 (PedsQL™) questionnaire. We determined the differences between groups on PedsQL™ mean scores, the proportion of children with an impaired HRQoL (≥ 1 SD lower than the healthy norm), the proportion of problems on individual items of the PedsQL™, and the effect of time on current treatment. Linear regression models were used to explore determinants of HRQoL. Results: 192 out of 278 patients (20% preemptive transplant, 58% non-preemptive transplant, 22% dialysis) filled in the PedsQL™ (response rate 69%). Independent of treatment modality, patients had significantly lower mean scores and consequently higher proportions of impaired HRQoL on almost all domains compared to the healthy norm and other chronic health conditions. Patients with a preemptive transplant only reported higher scores on physical health compared to the other treatment modalities. Having comorbidities was the most important determinant associated with lower HRQoL scores. Conclusion: Dialysis and renal transplantation both have a severe impact on the HRQoL of children with ESRD. Physicians should be aware of this continuous burden. Furthermore, to develop tailored interventions for children with ESRD, qualitative studies are needed to gain more insight in the determinants of HRQoL in the different treatment modalities.

KW - Adolescents

KW - End-stage renal disease

KW - Health-related quality of life

KW - Pediatrics

KW - Renal replacement therapy

UR - http://www.scopus.com/inward/record.url?scp=85041119656&partnerID=8YFLogxK

U2 - 10.1007/s11136-018-1789-4

DO - 10.1007/s11136-018-1789-4

M3 - Article

C2 - 29374855

AN - SCOPUS:85041119656

SN - 0962-9343

VL - 27

SP - 1445

EP - 1454

JO - Quality of Life Research

JF - Quality of Life Research

IS - 6

ER -

Splinter A, Tjaden LA, Haverman L, Adams B, Collard L, Cransberg K et al. Children on dialysis as well as renal transplanted children report severely impaired health-related quality of life. Quality of Life Research. 2018 jun. 1;27(6):1445-1454. doi: 10.1007/s11136-018-1789-4